Tau Blood Levels May Tell of Cognitive Decline Relationship between tau, cognitive problems not mediated by amyloid

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Tau Blood Levels May Tell of Cognitive Decline Relationship between tau, cognitive problems not mediated by amyloid

Elevated plasma total tau levels may be linked with cognitive decline, but the results differ depending on cognitive status and length of follow-up, researchers reported in JAMA Neurology.

In cognitively normal individuals, high levels of plasma total tau were associated with a risk of mild cognitive impairment. In people with mild cognitive impairment, however, plasma total tau levels were not associated with risk of dementia. Associations between total tau levels and cognition appeared to be independent of elevated brain amyloid beta, Michelle Mielke, PhD, of the Mayo Clinic College of Medicine, and colleagues found.


Original source of this content: https://www.medpagetoday.com/neurology/alzheimersdisease/66545