Scientists Select Potent Agonists to Target EphA4 in ALS

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Scientists Select Potent Agonists to Target EphA4 in ALS

EphA4 is emerging as a key obstacle in the repair and regeneration of motor neuronal axons. Blocking the activation of this receptor tyrosine kinase is showing promise as a potential treatment for spinal cord injury (Fabes et al., 2007Goldshmit et al, 2011). And, more recently, this strategy has been shown to protect motor neurons in ALS at the preclinical stage (van Hoecke et al., 2012). But there are 9 EphA receptors. Many of them are produced in motor neurons. Researchers have simply been unable to identify potent small molecule EphA4 blockers of sufficient selectivity to evaluate as a treatment for the disease. And, peptide antagonists are difficult to develop due to their inherent instability in circulation


Original source of this content: http://www.alsresearchforum.org/scientists-select-potent-agonists-to-target-epha4-in-als/